APPROACH TO STRAIN SELECTION AND THE PROPAGATION OF VIRAL STOCKS FOR VENEZUELAN EQUINE ENCEPHALITIS VIRUS VACCINE EFFICACY TESTING UNDER THE ANIMAL RULE

Licensure of a vaccine to protect against aerosolized Venezuelan equine encephalitis virus (VEEV) requires use of the U.S.Food and Drug Administration Therapuetic Skin (FDA) Animal Rule to assess vaccine efficacy as human studies are not feasible or ethical.An approach to selecting VEEV challenge strains for use under the Animal Rule was developed,

In earlier work, we have developed and evaluated an alternative approach to the analysis of GWAS data, based on a statistic called the PPLD.More recently, motivated by a GWAS for genetic modifiers of the X-linked Mendelian disorder Duchenne Muscular Dystrophy (DMD), we adapted the PPLD for application to time-to-event (TE) phenotypes.Because DMD it

Modern drug discovery and toxicological research are under pressure, MINT TOOTHPASTE as the cost of developing and testing new chemicals for potential toxicological risk is rising.Extensive evaluation of chemical products for potential adverse effects is a challenging task, due to the large number of chemicals and the possible hazardous effects on

Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development.Compared to commonly utilized mouse models, companion animals, specifically dogs and cats, share BLACKBERRY BETTY a closer phylogenetical distance, body size, and genome organization.Most importantly